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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database
Qualifier:
according to
Guideline:
other: Refer below principle
Principles of method if other than guideline:
Study was designed to assess the effect of test chemical on the mortality of fish.
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Fish
Test type:
not specified
Water media type:
not specified
Total exposure duration:
96 h
Hardness:
Not available
Test temperature:
Not available
pH:
Not available
Dissolved oxygen:
Not available
Salinity:
Not available
Nominal and measured concentrations:
Not available
Details on test conditions:
Not available
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
5.6 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Other details not known
Validity criteria fulfilled:
not specified
Conclusions:
The lethal concentration (LC50) value of test chemical in fish in a 96 hr study on the basis of mortality effect was determine to be 5.6 mg/L.
Executive summary:

Study was designed to assess the effect of test chemical on the mortality of fish. Test conducted for 96 hrs. The lethal concentration (LC50) value of test chemical in fish in a 96 hr study on the basis of mortality effect was determine to be 5.6 mg/L. The test chemical is highly insloluble in water the obtained LC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.

Description of key information

Study was designed to assess the effect of test chemical on the mortality of fish. Test conducted for 96 hrs. The lethal concentration (LC50) value of test chemical in fish in a 96 hr study on the basis of mortality effect was determine to be 5.6 mg/L. The test chemical is highly insloluble in water the obtained LC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.

Key value for chemical safety assessment

LC50 for freshwater fish:
5.6 mg/L

Additional information

Data available for the test chemical from various sources, study has been reviewed to determine the short term toxicity on fish of the test chemical. The studies are as mentioned below:

 

Study was designed to assess the effect of test chemical on the mortality of fish. Test conducted for 96 hrs. The lethal concentration (LC50) value of test chemical in fish in a 96 hr study on the basis of mortality effect was determine to be 5.6 mg/L. The test chemical is highly insloluble in water the obtained LC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.

 

Similar short term toxicity of test chemical were studied on the mortality of fish. The lethal concentration LC0, LC50 and LC 100 value of test chemical in fish (Brachydanio rerio) in a 96 hr study on mortality effect was determine to be 1,3.2 and 10 mg/L. The test chemical is highly insloluble in water the obtained LC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.

Thus based on the above data available from various sources, chemical consider to be non toxic at its maximum solubility limit.