Registration Dossier
Registration Dossier
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EC number: 610-122-1 | CAS number: 433733-94-9
Endpoint summary
Administrative data
Description of key information
Due to all technical measures to prevent contamination the exposure of the personnel is unlikely.
The following control measures have been identified as suitable control measures:
- Dust extraction units and laminar flow ventilation for charging/dischatging
- HVAC operates in all areas
- Regular maintenance is carried out on all ventilation installations.
- Respiratory protection equipment and personal protective equipment is specified
Process Safety Training regarding the use of control measures and the actions to be taken in the event of control measure failure is performed by the Process manager at the start of the production campaign and on a three-monthly basis thereafter.
The personal protective measure may be adapted appropriately when working in closed systems:
Respiration : Dust mask (tested in line with EN 149), approved respirator or airhood.
Filter : Combination filter
Eye : Wear approved safety glasses or visor
Hand : All KCL chemical protective gloves used on-site provide >8 hours protection
Additional protection : Wear chemical protective suit tested in line with EN 369/374-3
The site will be operating by the end of 2020 and it will be closed in 2021. The last campaign of DIACETYL-L-THYMIDINE production is planned in 2019.
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Due to all technical measures to prevent contamination the exposure of the personnel is unlikely.
The following control measures have been identified as suitable control measures:
- Dust extraction units and laminar flow ventilation for charging/dischatging
- HVAC operates in all areas
- Regular maintenance is carried out on all ventilation installations.
- Respiratory protection equipment and personal protective equipment is specified
Process Safety Training regarding the use of control measures and the actions to be taken in the event of control measure failure is performed by the Process manager at the start of the production campaign and on a three-monthly basis thereafter.
The personal protective measure may be adapted appropriately when working in closed systems:
Respiration : Dust mask (tested in line with EN 149), approved respirator or airhood.
Filter : Combination filter
Eye : Wear approved safety glasses or visor
Hand : All KCL chemical protective gloves used on-site provide >8 hours protection
Additional protection : Wear chemical protective suit tested in line with EN 369/374-3
The site will be operating by the end of 2020 and it will be closed in 2021. The last campaign of DIACETYL-L-THYMIDINE production is planned in 2019.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
