Registration Dossier
Registration Dossier
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EC number: 234-204-8 | CAS number: 10595-49-0
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Kronenberger et al (2007) determined that KEL3587 is readily biodegradable, passing the 10-day window.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
A reliable measured biodegradation study for KEL3587 is available and included in the dossier. Reliable studies are also available for the analogue, KEU4587, and are included in the dossier as supporting studies.
Kronenberger et al (2007) conducted a reliable (Klimisch 1) GLP compliant study according to OECD 301 B (CO2 evolution) methods. The biodegradability of KEL3587 exposed to microorganisms derived from activated sludge obtained from a municipal wastewater treatment plant was investigated under aerobic static exposure conditions. After 28 days the test substance showed 76.9% degradation, after acidification, based on measured CO2. The substance degraded 66% by the end of the 10-day window, meeting passing requirements. The study concluded that KEL3587 can be considered to be readily biodegradable, passing the 10-day window.
Kronenberger et al (2008) conducted a reliable (Klimisch 1) GLP compliant study according to OECD 301 B methods. The biodegradability of the analogue, KEU4587, exposed to microorganisms derived from activated sludge obtained from a municipal wastewater treatment plant was investigated under aerobic static exposure conditions. After 28 days the test substance showed 92.7% degradation, after acidification, based on measured CO2. The substance degraded 81.6% by the end of the 10-day window, meeting passing requirements. The study concluded that KEU4587 can be considered to be readily biodegradable, passing the 10-day window.
Junghans (2010) conducted a reliable (Klimisch 1) study according to OECD 311 methods. The ultimate biodegradability of the analogue, KEU4587, exposed to microorganisms derived from activated sludge obtained from a municipal wastewater treatment plant was investigated under anaerobic static exposure conditions. After 28 days the test substance showed 68% degradation, based on CO2 evolution. An adaptation period (lag phase) of about 2 -3 days was observed. The study concluded that KEU4587 can be considered to be ultimately biodegradable.
A reliable (Klimisch 1) biodegradation study has been conducted for KEL3587 and is included in this dossier. The key study, Kronenberger et al (2007), determined that KEL3587 is readily biodegradable, passing the 10-day window. Consequently this study will be taken for the biodegradation in water endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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