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EC number: 246-644-8 | CAS number: 25134-21-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Phototransformation in air
The stability of METH in the atmosphere was calculated using the software AOPWIN (v1.92). It is predicted that the substance will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals, with a half-life ranged from 4.24 and 6.52 hours.
The overall degradation rate constant with OH radicals is estimated ranged from 5.11E-6 to 7.84E-6 cm3/(molecule-day).
The stability of METHAc in the atmosphere was calculated using the software AOPWIN (v1.92). It is predicted that the substance will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals, with a half-life ranged from 4.10 to 6.19 hours.
The overall degradation rate constant with OH radicals is estimated ranged from 5.37E-6 to 8.11E-6 cm3/(molecule-day).
In the presence of moisture, 1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride (5-METH, 4-METH) rapidly hydrolyse to methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid (5-METHAc, 4-METHAc) and this entity is therefore more relevant to various environmental compartments than the submission substance.
Hydrolysis
The substance was highly unstable in water with a half-life in the order of minutes. Instability increased as temperature and pH increased.
Biodegradation
An experimental ready biodegradation test was conducted according to OECD TG 301C. The substance was exposed to activated sludge at 24.0 - 26.0 degree C for 28 days. No biodegradation occurred within this time period as indicated by both indirect and direct analyses. The substance is considered not to be biodegradable.
However the screening test inherent to the water biodegradability of the degradation product, calculated using the same software BIOWIN v4.10,indicate that the corresponding acids (4 -METHAc, 3 -METHAc) are expected to be readily biodegradable.
Bioaccumulation
The BCF was estimated using accepted calculation methods.
EPA BCFBAF v.3.01 gives a value of 3.16 L/Kg ww for the corresponding hydrolysis product,methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid (METHAc).
These are in line with experimental data which resulted in a range 3.9 - 5.5
It is therefore concluded that the potential for bioaccumulation of 1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride (METH) is low.
Adsorption / desorption
The adsorption coefficients on soil of the registered substance (Koc,n: METH) and the corresponding acid (Koc,i: METHAc) were calculated according to the EPA model KOCWIN (v2.00).
It was verified, using the Log Kow method, that Koc,i < Koc,n.
According to the McCall classification scheme, both the anhydride and acid forms are very highly mobile (0 < Koc < 50) on soil.
The higher value of the anhydride form, Koc= 25.5 L/Kg, was selected with conservative approach for the environmental assessment.
Henry's Law constant
The Henry's Law constants were estimated using the software HENRYWIN (v3.20).
The HLCs of methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid (METHAc) in its identified isomeric forms, as hydrolysis products of 1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride, were considered for the environmental assessment.
The value of 5.6E-07 Pa m³/mol, as a mean of estimated values, indicates that METHAc is essentially non volatile from surface water.
Distribution modelling
Distribution modelling
Distribution in environmental compartments has been calculated using a Fugacity model, under the emission scenario of 1000 kg/h into each of air, water and soil compartments, according to Mackay, Level III.
The distribution of 5-methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid (5-METHAc) was estimated as: Air= 0.0%; Water= 34.6%; Soil= 65.4% and Sediment= 0.06%.
The distribution of 1-methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid (4-METHAc) was estimated as: Air= 0.0%; Water= 34.5%; Soil= 65.5% and Sediment= 0.06%.
The soil, and less water, were then found to be the major target compartments.
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