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Registration Dossier
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EC number: 604-138-8 | CAS number: 139481-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant study. Adequate for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- no data
- GLP compliance:
- yes
Test material
- Reference substance name:
- CAN6
- IUPAC Name:
- CAN6
- Test material form:
- other: The test substance was moistened with sterile water in order to allow good contact between the test substance and the skin
- Details on test material:
- Appearance: White crystals.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
- Details on test animals or test system and environmental conditions:
- Sex: Female.
Body weight: between 2.0 kg and 2.5 kg at the start of the experiment.
Feed and water were available ad libitum.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: The test substance was moistened with sterile water
- Controls:
- other: Adjacent surfaces of untreated skin served as a control for the trial.
- Amount / concentration applied:
- 0.5 g of the substance was applied on the skin of the righi flank region.
- Duration of treatment / exposure:
- each animal received one patch far an exposure period of four hours.
- Observation period:
- One hour, 24 hours, 48 hours and 72 hours approximately after removal of the dressing, any skin lesions, which ha ve developed on the right flank of each animal, w ere evaluated.
- Number of animals:
- 3
- Details on study design:
- no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Score:
- 0
- Remarks on result:
- other: The score is related to 1, 24, 48 and 72 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Score:
- 0
- Remarks on result:
- other: The score is related to 1, 24, 48 and 72 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Score:
- 0
- Remarks on result:
- other: The score is related to 1, 24, 48 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Score:
- 0
- Remarks on result:
- other: The score is related to 1, 24, 48 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Score:
- 0
- Remarks on result:
- other: The score is related to 1, 24, 48 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Score:
- 0
- Remarks on result:
- other: The score is related to 1, 24, 48 and 72 hours.
- Irritant / corrosive response data:
- no data
- Other effects:
- no other effects were observed.
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions adopted, the substance was found to be non irritant for the skin of the rabbit.
- Executive summary:
Under the experimental conditions adopted, the substance was found to be non irritant for the skin of the rabbit.
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