5-methylheptan-3-one

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1949

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well documented non-GLP study for several substances

Data source

Reference

Reference Type:

publication

Title:

Range-finding toxicity data: List III

Author:

Smyth HF. Jr, Carpenter CP., Weil CS.

Year:

1949

Bibliographic source:

Journal. Ind. Hyg. and Tox, Issue 1 (31): p60, 1949

Materials and methods

Principles of method if other than guideline:

Six male albino rats were exposed for 4 hours to a flowing stream of vapors with known vapour concentrations of 3-heptanone
The chosen concentrations were in a geometric series with a factor of 2.

GLP compliance:

no

Remarks:

study performed before the introduction of GLP

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-Heptanone

IUPAC Name:

3-Heptanone

Constituent 2

Reference substance name:

Heptan-3-one

EC Number:

203-388-1

EC Name:

Heptan-3-one

Cas Number:

106-35-4

Molecular formula:

C7H14O

IUPAC Name:

heptan-3-one

Test animals

Species:

rat

Strain:

other: Sherman or Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

Rats weighing ca. 120 g.

Administration / exposure

Route of administration:

inhalation: vapour

Vehicle:

air

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

4 h

Concentrations:

Concentrations ranged from 2000 ppm to 4000 ppm. The chosen concentrations were in a geometric series with a factor of 2.

No. of animals per sex per dose:

6

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LC0

Effect level:

9.4 mg/L air

Exp. duration:

4 h

Effect levels 2

Sex:

male

Dose descriptor:

LC100

Effect level:

18.9 mg/L air

Exp. duration:

4 h

Mortality:

Mortality was observed after dosing of 3-heptanone and was considered complete 14 days after dosing.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information according to EU GHS Criteria used for interpretation of results: EU

Conclusions:

3-Heptanone is toxic by inhalation category 4 according to the EU classification system. Similarly, it is harmful by inhalation (R20) according to directive 67/548/EEC

Executive summary:

Acute inhalative toxicity to rats of 3-heptanone was investigated in a vapor single-dose exposure study. Dosing was performed by exposing the animal to a stream of air saturated with 3-heptanone and mortality was observed for 14 days after dosage. Groups of 6 male animals were used per dose. The LC0 for 3-heptanone was 9.4 mg/L air and the LC100 was 18.9mg/L. Therefore, the LC50

of 3-heptanone lies within the range for the classification as inhalation acute toxic IV according to according to Regulation 1272/2008/EC (10<LC50<20mg/L). For the same reason, 3-heptanone is classified as harmful by inhalation (R20) according to directive 67/548/EEC.