Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

repeated dose toxicity: dermal
Data waiving:
exposure considerations
Justification for data waiving:

Data source

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

C36-alkylenediaminehas proven to be severely irritating to skin showing to beirreversible within the 14-day observation period, and corrosive to the eyes. Following these dermal irritative / corrosive properties, dermal exposure has to be limited / minimized.C36-alkylenediamineis only used as intermediate in industrial settings where adequate PPE are applied, limiting direct dermal exposures. Consequently, skin contact in production and/or use is not likely. Testing by the dermal route is therefore not appropriate as stipulated in Annex IX, point 8.6.2, column 2 of REACH regulation (EC) 1907/2006.

Also available information suggests that dermal route is not the most sensitive route of exposure. Furthermore, following the severe irritating / corrosive properties of the substance, dermal testing should not be performedalso based on animal welfare grounds.