Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 250-196-9 | CAS number: 30433-91-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 17 March 1994 to 16 September 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A well documented not GLP study according to OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Thiophene-2-ethylamine
- EC Number:
- 250-196-9
- EC Name:
- Thiophene-2-ethylamine
- Cas Number:
- 30433-91-1
- Molecular formula:
- C6H9NS
- IUPAC Name:
- 2-(2-thienyl)ethanamine
- Reference substance name:
- 2-Thiopheneethanamine
- IUPAC Name:
- 2-Thiopheneethanamine
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): SR 26825
- Lot/batch No.: 4SNL001
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: OFA-SD (IOPS Caw)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Credo
- Age at the beginning of the treatment: approximately 5 weeks
- Weight at the beginning of the treatment: male: 115 to 184 g - female: 122 to 152 g
- Fasting period before treatment: food was withdrawn 18 hours before treatment and redistributed approximately 4 hours after treatment
- Housing: rats were housed 2 or 3 of a same group to stainless steel cages (891cm² x 18 cm).
- Diet: UAR AO4C diet
- Water: tap water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22°C (+/- 2°C)
- Humidity: between 40 and 70%
- Air changes: 10 to 11 times per hour without recycling
- Photoperiod: 12/24-hour light cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: in a 0.6% methylcellulose aqueous solution
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.6% in methylcellulose aqueous solution
- Administration volume: 10 mL/kg
Dose levels were selected in view of available information on the test compound. - Doses:
- Dose levels: 0, 125, 200, 250, 500 and 2000 mg/kg
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing:
Clinical signs: daily observations
Body weight: day 1 (on the day of treatment) and on day 3, day 8 and day 15.
- Post-mortem macroscopic examination was performed in the animals found dead during the study.
- Surviving animals were sacrificed by an intraperitoneal injection of pentobarbital sodium followed by exsanguination and subjected to a macroscopic examination at the end of observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 200 other: mg/kg
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - <= 250 other: mg/kg
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD100
- Effect level:
- 500 other: mg/kg
- Based on:
- test mat.
- Mortality:
- No mortality occurred for the dose levels: 0, 125 and 200 mg/kg
At 250 mg/kg: 3 males (of 5) and 3 females (of 5) died 3h30 following treatment
At 500 mg/kg: 3 males died in the first hour and 2 other males died, 3h30 following treatment. As for the females, 4 died in the first hour and 1 died, 3h30 following treatment.
At 2000 mg/kg: 2 males died 30 minutes following treatment and the other 3 males died 45 minutes following treatment. As for the females, the 5 animals died 30 minutes following treatment.
Mortality occurred very soon after treatment. - Clinical signs:
- other: >= 125 mg/kg: Ptyalism (day 1) >= 200 mg/kg: Prostration (day 1) in surviving animals a few hours after treatment >= 250 mg/kg: Decubitus, tremors, clonic convulsions (day 1) 2000 mg/kg: Piloerection (on day 1 in 3 males only)
- Gross pathology:
- Observations after necropsy:
- Animals found dead:
>= 250 mg/kg: Intestine and stomach: hemorrhagic contents in all animals; Lungs: non collapsed mostly at 250 mg/kg; Dried blood on the muzzle (3/6 at 250 mg/kg, 8/10 at 500 mg/kg)
>= 500 mg/kg: Liver: slightly pale in all animals
2000 mg/kg: Stomach (glandular area): red spots in all animals
- Animals sacrificed on day 15: No treatment-related changes
Applicant's summary and conclusion
- Conclusions:
- The maximal non lethal dose is 200 mg/kg in male and female rats. LD50 is between 200 and 250 mg/kg. No intersex differences were noted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
