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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-formyl-4-nitrophenoxy)hexanoic acid
EC Number:
608-880-3
Cas Number:
335153-21-4
Molecular formula:
C13H15NO6
IUPAC Name:
2-(2-formyl-4-nitrophenoxy)hexanoic acid

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
1 male and 2 females; females were nulliparous and non-pregnant. Ambient temperature @20°C with 30-70% humidity. 10-15 air exchanges per hour. 12 hourlight/dark cycle, full spectrum fluorescent lights.

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
100mg
Duration of treatment / exposure:
Material administered to the eye for a few seconds then animal observed for 24,48 and 72 hours
Observation period (in vivo):
24,48 and 72 hours
Number of animals or in vitro replicates:
1 male and 2 females

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: 1hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hour
Irritation parameter:
other: Redness
Basis:
animal #1
Time point:
other: 1hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Discharge
Basis:
animal #1
Time point:
other: 1 hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: 1hr
Score:
4
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Redness
Basis:
animal #2
Time point:
other: 1hr
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Discharge
Basis:
animal #2
Time point:
other: 1 hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Opacity
Basis:
animal #2
Time point:
other: 1 hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Area covered
Basis:
animal #2
Time point:
other: 1 hr
Score:
4
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
other: 1 hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Redness
Basis:
animal #3
Time point:
other: 1 hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Discharge
Basis:
animal #3
Time point:
other: 1hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Opacity
Basis:
animal #3
Time point:
other: 1hr
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 96 hours
Irritation parameter:
other: Area covered
Basis:
animal #3
Time point:
other: 1hr
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 96 hours

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The material is considered to be an eye irritant.
Executive summary:

The material is considered to be an eye irritant.