Butan-2-one O,O',O'',O'''-silanetetrayltetraoxime

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH
The target substance TOS is an oxime silane that undergoes rapid hydrolysis in aqueous to MEKO and the corresponding silanol. At the same time, silanols undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the toxicity of TOS is due to the hydrolysis product MEKO and their values are comparable.
See attached reporting format.

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

214.88 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(analogue substance)

Basis for effect:

mobility

Remarks on result:

other: (Based on read-across approach from an analogue

Details on results:

Based on the experimental results obtained with the analogue substance butanone oxime (48h EC50 =201 mg/L ), the read-across approach is applied and the 48h EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 214.88 mg/L.

Validity criteria fulfilled:

not applicable

Conclusions:

Based on the read-across approach from experimental results on analogue butanone oxime, 48 -EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Daphnids was determined to be 214.88 mg/L.

Executive summary:

A Daphnia Acute Immobilisation Test was performed on analogue substance butanone oxime by the Ministry of Environment of Japan according to OECD TG 202. The 48h-EC50 was determined to be 201 mg/L. Based on these results, the read-across was applied and the 48 -EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Daphnids was determined to be 214.88 mg/L.

Description of key information

Key study: Read-across from experimental data on analogue butanone oxime: The 48h-EC50 ofbutan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Daphnids was determined to be 214.88 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Dose descriptor:

EC50

Effect concentration:

214.88 mg/L

Additional information

Key study: Read-across approach from analogue butanone oxime:

Based on the read-across approach from experimental results on analogue butanone oxime (test method OECD 202, 48h-LC50 Daphnids = 201 mg/L), the 48h-EC50 of butan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Daphnids was determined to be 214.88 mg/L.