Reaction mass of 2-{[2-(2-hydroxyethoxy)ethoxy]carbonyl}benzoic acid and 2,2'-oxydiethanol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2012-03-30 till 2012-04-18

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

The water solubility of the test substance in demineralized water in ratios 1:10, 1:1 and 10:1 is observed by a preliminary test.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: The column elution method for solubility < 10-2 g/L and the flask method for solubility ≥10-2 g/L.

Water solubility:

> 10 g/L

Temp.:

20 °C

Remarks on result:

completely miscible

Details on results:

The results of the tests show, that the test substance is soluble in demineralized water in each ratio to clear homogenous solutions.

For all tested ratios clear solutions were received. No phase separations or sedimentations were observed. The solutions were stored at 20 °C for 24 hours and observed again. No phase separations or sedimentations were observed as well.

Conclusions:

Interpretation of results (migrated information): miscible
The results of the tests show, that the test substance is soluble in demineralized water in each ratio to clear homogenous solutions (Neuland, 2012).

Executive summary:

The water solubility of the test substance was determined with two different methods, the column elution method for solubility <0.01 mg/L and the flask method for solubility ≥0.01 mg/L according to OECD Guidelines for Testing of Chemicals, Section 1 – Physical-Chemical Properties No: 105 “Water Solubility”, (adopted, July 1995) and corresponds to Council Regulations EC No 440/2008, Guideline Part A – Methods for the Determination of Physico-Chemical Properties, A.6. “Water Solubility” (adopted, May 2008).

The water solubility of the test substance in demineralized water in ratios 1:10, 1:1 and 10:1 is observed by a preliminary test. In case the test item is soluble in each ratio, no further water solubility tests by column elution method or flask method are necessary.

Description of key information

The results of OECD Guideline test 105 show, that the test substance is soluble in demineralized water in each ratio to clear homogenous solutions.

Key value for chemical safety assessment

Water solubility:

10 000 mg/L

at the temperature of:

20 °C

Additional information

The substance was miscible in any tested concentration. Thus, the key value should be understood as >10 g/L.