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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
yes
Type of study:
Buehler test

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3,5-triisopropylbenzene
EC Number:
211-941-3
EC Name:
1,3,5-triisopropylbenzene
Cas Number:
717-74-8
Molecular formula:
C15H24
IUPAC Name:
1,3,5-tris(propan-2-yl)benzene

In vivo test system

Test animals

Species:
guinea pig
Strain:
Hartley
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
other: acetone
Concentration / amount:
induction: 25-50%
challenge: 12.5%
Challengeopen allclose all
Route:
epicutaneous, open
Vehicle:
other: acetone
Concentration / amount:
induction: 25-50%
challenge: 12.5%
No. of animals per dose:
10
Details on study design:
The Buehler test used three six-hour applications at one - week intervals, followed by a challenge two weeks later.
Positive control substance(s):
no

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
12.5%
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: 12.5%. No with. + reactions: 0.0. Total no. in groups: 10.0.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The test material, 1,3,5-triisopropylbenzene (TIPB) was determined to be non-sensitizing in guinea pigs
Executive summary:

The potential for 1,3,5 -triisopropylbenzene (TIPB) to induce dermal sensitization was evaluated using a Buehler test in guinea pigs. A total of 10 guinea pigs were used in this study. For the induction phase, material (50% in acetone) was applied topically to each animal for 6 hours, and this was repeated weekly for a total of 3 applications. Animals were challenged 2 weeks after the last induction treatment using a 12.5% solution of TIPB in acetone. Data indicate that sensitization was not observed in any of the guinea pigs, indicating that TIPB is non-sensitizing.