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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Code of Federal Regulations, Title 16, Section 1500.41
Principles of method if other than guideline:
500 µl of phenyl isocyanate was applied on a 2.5 x 2.5 cm² area at the shaved (one side) and scarified (other side) trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24, 48 and 72 h after start of application.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenyl isocyanate
EC Number:
203-137-6
EC Name:
Phenyl isocyanate
Cas Number:
103-71-9
Molecular formula:
C7H5NO
IUPAC Name:
isocyanatobenzene

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: shaved and scarified
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period:
8 days
Number of animals:
6 animals

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24, 72 h
Score:
>= 2
Max. score:
8
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: no erythema score available after 24 and 72 h due to white discoloration of the skin
Irritant / corrosive response data:
Erythema score = 4 (after 8 days), edema score = 4 (24, 72 hours and 8 days).
Other effects:
White discoloration of the skin within 24 hours. Dryness, folding and red-brownish discoloration of the skin after 72 hours. Dry eschar formation after 8 days and beginning of ablation. No hair growth under eschar.

Any other information on results incl. tables

Phenyl isocyanate is strong irritant/corrosive to the skin.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
Phenyl isocyanate was regarded as strong irritant/corrosive to the skin. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Skin Corr. 1 is justified.
Executive summary:

500 µl of the phenyl isocyanate was applied on a 2.5 x 2.5 cm² area at the shaved (one side) and scarificed (other side) trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24 and 72 h after start of application.

Within 24 hours a white discoloration of the skin occurs, followed by dryness, folding of the skin after 72 hours. A dry eschar formation after 8 days and beginning of ablation was observed. No hair growth under the eschar.

The primary irritation index was> 2.0. Phenyl isocyanate was regarded as strong irritant/corrosive to the skin.