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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
2.27 g/L
Temp.:
20 °C
pH:
7.5
Remarks on result:
other: Range: 2.23 to 2.34 g/L

The concentration determination is performed according to Absolute Calibration Curve Method using the peak area (n=3).

The peak area relating to the standard and sample solutions are detailed below:

Injection Solutions data (n=3)

Standard (mg/L)  Area(m/z 253.10)
6.35  3433950
6.35  3421419
6.35  3421389
15.87  6878846
15.87  6859050
15.87  6750066
39.68  12620710
39.68  13036017
39.68  12989015
63.49  19466582
63.49  19647481
63.49  19549858

Sample (diluted)  Area(m/z 253.10) 
1day  8150570
1day  8196140
1day  8229326
2days  7989221
2days  8139905
2days  8338934
3days  8435353
3days  8523844
3days  8473963

*1day: 24 hours shaken at 30℃ and 24h held at 20℃.

*2days: 48 hours shaken at 30℃ and 24h held at 20℃.

*3days: 72 hours shaken at 30℃ and 24h held at 20℃.

Regression line and the correlation coefficient

Conc. (mg/L) = 276848 x Area + 1994434

R2 = 0.998

Quantification data (n=3)

Area ave.  Conc. (mg/L)  Neat liquid conc.(g/L)  pH (Neat liq.)
1day  8192012 22.4  2.24  7.5
2days  8156020 22.3  2.23  7.5
3days  8477720 23.4  2.34  7.5

Mean concentration: 2.27 g/L

Range: 2.23 to 2.34 g/L

Conclusions:
The water solubility of Coolact 10 has been determined to be 2.27 g/L of solution at a temperature of 20.0 ± 0.5°C.
Executive summary:

The aim of the study was to determine the water solubility of Coolact 10 following the OECD guideline n°105.

The flask shaking method was used.

The water solubility of Coolact 10 has been determined to be 2.27 g/L of solution at a temperature of 20.0 ± 0.5°C.

Description of key information

The water solubility of the test material was determined to be 2.27 g/L of solution at a temperature of 20.0 ± 0.5°C.

Key value for chemical safety assessment

Water solubility:
2.27 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was determined in accordance with the standardised guideline OECD 105 following the flask method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study the water solubility of the test material was determined to be 2.27 g/L of solution at a temperature of 20.0 ± 0.5°C.

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