3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Type of method:

flask method

Water solubility:

2.27 g/L

Temp.:

20 °C

pH:

7.5

Remarks on result:

other: Range: 2.23 to 2.34 g/L

The concentration determination is performed according to Absolute Calibration Curve Method using the peak area (n=3).

The peak area relating to the standard and sample solutions are detailed below:

Injection Solutions data (n=3)

Standard (mg/L)	Area(m/z 253.10)
6.35	3433950
6.35	3421419
6.35	3421389
15.87	6878846
15.87	6859050
15.87	6750066
39.68	12620710
39.68	13036017
39.68	12989015
63.49	19466582
63.49	19647481
63.49	19549858

Sample (diluted)	Area(m/z 253.10)
1day	8150570
1day	8196140
1day	8229326
2days	7989221
2days	8139905
2days	8338934
3days	8435353
3days	8523844
3days	8473963

*1day: 24 hours shaken at 30℃ and 24h held at 20℃.

*2days: 48 hours shaken at 30℃ and 24h held at 20℃.

*3days: 72 hours shaken at 30℃ and 24h held at 20℃.

Regression line and the correlation coefficient

Conc. (mg/L) = 276848 x Area + 1994434

R2 = 0.998

Quantification data (n=3)

	Area ave.	Conc. (mg/L)	Neat liquid conc.(g/L)	pH (Neat liq.)
1day	8192012	22.4	2.24	7.5
2days	8156020	22.3	2.23	7.5
3days	8477720	23.4	2.34	7.5

Mean concentration: 2.27 g/L

Range: 2.23 to 2.34 g/L

Conclusions:

The water solubility of Coolact 10 has been determined to be 2.27 g/L of solution at a temperature of 20.0 ± 0.5°C.

Executive summary:

The aim of the study was to determine the water solubility of Coolact 10 following the OECD guideline n°105.

The flask shaking method was used.

The water solubility of Coolact 10 has been determined to be 2.27 g/L of solution at a temperature of 20.0 ± 0.5°C.

Description of key information

The water solubility of the test material was determined to be 2.27 g/L of solution at a temperature of 20.0 ± 0.5°C.

Key value for chemical safety assessment

Water solubility:

2.27 g/L

at the temperature of:

20 °C

Additional information

The water solubility of the test material was determined in accordance with the standardised guideline OECD 105 following the flask method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study the water solubility of the test material was determined to be 2.27 g/L of solution at a temperature of 20.0 ± 0.5°C.