2-methylbutyl acrylate

Endpoint summary

Key value for chemical safety assessment

Effects on developmental toxicity

Additional information

In study #1, no effects on reproductive organs of either sex were reported at the highest dose tested.

In study #2, no pathology was attributed to the test substance. In the mid- and high-dose groups(135 and 250 ppm), the percentage of live implantations was decreased in a dose-dependent manner and the number of resorptions was increased. No treatment related malformations , skeletal abnormalities or organ changes were seen in the fetuses at any concentration.

 

In study #3, no test substance related effects were seen in the number of implantation sites, live fetuses, non-live implants or resorptions. Fetal body weights were reduced in the mid- and high-dose (200 and 300 ppm) groups. No treatment related effects were seen on the incidence of external and internal variations and the incidence of skeletal variations was similar in the control and treated groups.

 

In study #4, a reduction in body fetal body weight was seen at doses above 1500 mg/kg; resorptions were increased above 2500 mg/kg. In the control, 100 mg/kg, 1000 mg/kg, 1500 mg/kg and 2000 mg/kg variations and malformations occurred sproradically and on different sides in a non-dose-dependent manner. In the higher dose groups, 2500 mg/kg and 3000 mg/kg, the number of fetuses with external and skeletal malformations was significantly increased.

Data matrix – Analog approach
	Target substance	Source substance (1)
CHEMICAL NAME	2-methylbutyl acrylate	n-butyl acrylate
CAS#	44914-03-6	141-32-2
Molecular formula	C8H14O2	C7H12O2
Molecular Weight	142.2	128.2
PHYSICO-CHEMICAL DATA
Melting Point	Experimental: ≤ -75 °C	Not available
Boiling Point	Experimental: 161.7 °C at 1013hPa	Experimental: 147 °C at 1013hPa
Density	Experimental: 0.8886 g/cm3 at 25 °C	Experimental: 0.9 g/cm3 at 20.0 °C
Vapour Pressure	Experimental: 1.7 hPa at 20°C	Experimental: 5 hPa at 22.2°C
Partition Coefficient (log KOW)	Experimental: 2.9	Experimental: 2.38 (at 25°C)
Water Solubility	Experimental: 316 mg/L at 23 °C	Not available
MAMMALIAN TOXICITY
Reproductive Effects	Readacross from source (1): NOAEC for effects on reproductive organs:  546 ppm  (highest dose tested)	Experimental: NOAEC for effects on reproductive organs:  546 ppm  (highest dose tested)
Developmental/Teratogenicity Study in Rats via inhalation	Readacross from source (1): NOAEC embryotoxicity:  25 ppm NOAEC maternal toxicity: 25 ppm NOAEC teratogenicity:  250 ppm	Experimental: NOAEC embryotoxicity:  25 ppm NOAEC maternal toxicity: 25 ppm NOAEC teratogenicity:  250 ppm
Developmental/Teratogenicity Study in Rats via inhalation	Readacross from source (1): LOAEC maternal toxicity:  100 ppm NOAEC fetotoxicity:  100 ppm NOAEC teratogenicity:  300 ppm	Experimental: LOAEC maternal toxicity:  100 ppm NOAEC fetotoxicity:  100 ppm NOAEC teratogenicity:  300 ppm
Developmental Toxicity Study in mice via oral gavage	Readacross from source (1): NOAEL Maternal Toxicity:  100 mg/kg NOAEL Developmental Toxicity:  1000 mg/kg NOAEL Teratogenicity:  2000 mg/kg	Experimental: NOAEL Maternal Toxicity:  100 mg/kg NOAEL Developmental Toxicity:  1000 mg/kg NOAEL Teratogenicity:  2000 mg/kg

Justification for classification or non-classification

The data do not support the classification as a reproductive or developmental substance.