Isopropyl acetoacetate

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2020-04-30 to 2020-05-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

185 °C

Atm. press.:

1 013 hPa

Decomposition:

no

In the temperature range of -50 °C to -10 °C, an endothermic effect (melting) was observed. In the temperature range of 140 °C - 200 °C a second endothermic effect could be detected.

Measurement No.	Sample weight / mg	Onset of Effect / °C	Range of effect / °C	Weight loss / mg	Atmospheric pressure / hPa
PN19622	11.10	-31.40 184.05	-50 to -10 (endo) 140 to 200 (endo)	11.08	991.9
PN19627	10.30	-32.36 184.35	-50 to -10 (endo) 140 to 200 (endo)	10.28	991.8

During the heating phase a distinct endothermic effect was observed in the temperature range of -50 to -10 °C, which can be assigned to the melting of the test item.

The test item showed a second endothermic effect in the temperature range of 140 °C - 200 °C, which can be assigned to the boiling of the test item.

As the onset temperatures in both tests do not deviate by more than 0.5 K from their mean value of 184.20 °C, this temperature can be used as boiling point. With correction for the air pressure (991.9 and 991.8 mbar, respectively) the boiling point of the test item is 185.0 °C, which could be confirmed by the photo cell detection method (184.0 °C at 1019 mbar).

No further thermal effects were observed up to the test end temperature of 500 °C.

Conclusions:

The corrected boiling point of the test item was determined to be 185.0 °C at 1013 hPa.

Executive summary:

The boiling point of the test item was determined by Differential Scanning Calorimetry and confirmed by the photo cell detection method according to Regulation (EC) No 440/2008 Method A.2. and OECD Test Guideline 103 (1995). The test item was cooled down to -90 °C and then heated up to 500 °C at a constant heating rate of 10 K/min. The test item showed an endothermic effect in the temperature range of 140 °C - 200 °C, which can be assigned to the boiling of the test item. As the onset temperatures in both tests do not deviate by more than 0.5 K from their mean value of 184.20 °C, this temperature can be used as boiling point. With correction for the air pressure (991.9 and 991.8 mbar, respectively) the boiling point of the test item is 185.0 °C at 1013 hPa, which could be confirmed by the photo cell detection method (184.0 °C at 1019 mbar).

Description of key information

The corrected boiling point of the test item was determined to be 185.0 °C at 1013 hPa (reference 4.3 -1).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

185 °C

Additional information

The boiling point of the test item was determined by Differential Scanning Calorimetry and confirmed by the photo cell detection method according to Regulation (EC) No 440/2008 Method A.2. and OECD Test Guideline 103 (1995). The test item was cooled down to -90 °C and then heated up to 500 °C at a constant heating rate of 10 K/min. The test item showed an endothermic effect in the temperature range of 140 °C - 200 °C, which can be assigned to the boiling of the test item. As the onset temperatures in both tests do not deviate by more than 0.5 K from their mean value of 184.20 °C, this temperature can be used as boiling point. With correction for the air pressure (991.9 and 991.8 mbar, respectively) the boiling point of the test item is 185.0 °C at 1013 hPa, which could be confirmed by the photo cell detection method (184.0 °C at 1019 mbar).