Registration Dossier
Registration Dossier
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EC number: 200-618-2 | CAS number: 65-85-0
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Female Wistar rats were co-housed overnight in cages with males and examined for sperm the next morning. After confirmation of pregnancy, females were housed 2 animals/cage, and allowed commercial chow and water ad libitum. Benzoic acid was not the primary test article in this study, but was used to prolong clearance of salicylic acid. To this end, a separate group of females received benzoic acid alone on GD 9. Animals were euthanized on GD 20.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Benzoic acid
- EC Number:
- 200-618-2
- EC Name:
- Benzoic acid
- Cas Number:
- 65-85-0
- Molecular formula:
- C7H6O2
- IUPAC Name:
- benzoic acid
- Details on test material:
- Purity: not specified Batch No.: NCEL No. 817
Constituent 1
- Specific details on test material used for the study:
- Not stated.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Animals were housed in metabolism cages.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Single exposure.
- Frequency of treatment:
- Single exposure.
- Duration of test:
- Benzoic acid was administered on GD 9.
Doses / concentrations
- Dose / conc.:
- 510 mg/kg bw (total dose)
- Remarks:
- Benzoic acid was given by gavage to impact salicylic acid clearance.
- No. of animals per sex per dose:
- 7 females in the "benzoic acid alone" group.
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Although benzoic acid was not the primary subject of this study, one group of 7 females was treated with 510 mg/kg bw benzoic acid to prolong clearance of salicylic acid. Malformations and resorption rates after benzoic acid alone were comparable to those in control animals.
- Executive summary:
Although benzoic acid was not the primary subject of this study, one group of 7 females was treated with 510 mg/kg bw benzoic acid to prolong clearance of salicylic acid. Malformations and resorption rates after benzoic acid alone were comparable to those in control animals.
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