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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-10-27
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
not specified
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
- Analytical purity: > 98% GC purity
- Lot/batch No.: 581017
- Storage condition of test material: room temperature
Key result
Water solubility:
101 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
500 g/L
Incubation duration:
>= 24 - <= 108 h
Temp.:
20
pH:
2.3
Remarks on result:
completely miscible

Triplicate: saturated solutions were agitated at 30 °C for the time indicated in the table. 

Afterwards, each flask was allowed to equilibrate for 24 h at 20 °C.

After centrifugation and filtration (0.45 µm filter) the content of the substance in the aqueous phase was determined by HPLC with UV-detector.

 

Flask

Water Solubility (g/l)

1 (24h)

106.9

2 (48h)

97.2

3 (108h)

99.1

Conclusions:
The water solubility of Bis-MPA at 20 °C is 101 g/L, hence the substance is classified as very soluble (> 10000 mg/L).
Executive summary:

In a study according to OECD guideline 105 the solubility of Bis-MPA was determined to be 101 g/L at 20 °C.

Description of key information

In a study according to OECD guideline 105 the solubility of Bis-MPA was determined to be 101 g/L at 20 °C.

Key value for chemical safety assessment

Water solubility:
101 g/L
at the temperature of:
20 °C

Additional information