2,2-bis(hydroxymethyl)propionic acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-10-27

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

not specified

GLP compliance:

no

Type of method:

flask method

Specific details on test material used for the study:

- Analytical purity: > 98% GC purity
- Lot/batch No.: 581017
- Storage condition of test material: room temperature

Key result

Water solubility:

101 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

500 g/L

Incubation duration:

>= 24 - <= 108 h

Temp.:

20

pH:

2.3

Remarks on result:

completely miscible

Triplicate: saturated solutions were agitated at 30 °C for the time indicated in the table. 

Afterwards, each flask was allowed to equilibrate for 24 h at 20 °C.

After centrifugation and filtration (0.45 µm filter) the content of the substance in the aqueous phase was determined by HPLC with UV-detector.

 

Flask	Water Solubility (g/l)
1 (24h)	106.9
2 (48h)	97.2
3 (108h)	99.1

Conclusions:

The water solubility of Bis-MPA at 20 °C is 101 g/L, hence the substance is classified as very soluble (> 10000 mg/L).

Executive summary:

In a study according to OECD guideline 105 the solubility of Bis-MPA was determined to be 101 g/L at 20 °C.

Description of key information

In a study according to OECD guideline 105 the solubility of Bis-MPA was determined to be 101 g/L at 20 °C.

Key value for chemical safety assessment

Water solubility:

101 g/L

at the temperature of:

20 °C