Registration Dossier
Registration Dossier
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EC number: 202-396-2 | CAS number: 95-16-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1995
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only extended abstract available
Data source
Reference
- Reference Type:
- publication
- Title:
- The role of aldehyde oxidase in the in vivo metabolism of benzothiazole
- Author:
- Fowler et al.
- Year:
- 1 995
- Bibliographic source:
- Biochem Soc Trans 23, 604S
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single i.p. administration to guinea pigs, identification of urinary and faecal metabolites
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzothiazole
- EC Number:
- 202-396-2
- EC Name:
- Benzothiazole
- Cas Number:
- 95-16-9
- Molecular formula:
- C7H5NS
- IUPAC Name:
- benzothiazole
- Details on test material:
- - Name of test material (as cited in study report): [³H]-benzothiazole
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Methocel KI5M Premium
- Duration and frequency of treatment / exposure:
- Single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
44 mg/kg bw
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine and faeces were collected on a 24h basis and analysed immediately
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Metabolism of 6-[³H]-benzothiazole:
1) 3.5 % 2-methylmercaptoaniline
2) 55 % 2-methylsulphinylaniline
3) 15.5 % 2-methylsulphonylaniline
Applicant's summary and conclusion
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