Registration Dossier
Registration Dossier
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EC number: 212-836-5 | CAS number: 873-32-5
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- BUA-Stoffbericht 265 - 2-Chlorbezonitril, 4-Chlorbenzonitril
- Author:
- n.a.
- Year:
- 2 006
- Bibliographic source:
- Beratergremium für Altstoffe (BUA) der Gesellschaft Deutscher Chemiker, S.Hirzel Wissenschaftliche Verlagsgesellschaft
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Hydrolysis of 2-chlorobenzonitrile was followed by incubation of 0.14 mg/L = 1 µmol/L test substance in sediment samples of an eutrophic pond situated in the Netherlands at 22 °C and pH = 7.3. Hydrolysis was terminated by addition of acetonitrile.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chlorobenzonitrile
- EC Number:
- 212-836-5
- EC Name:
- 2-chlorobenzonitrile
- Cas Number:
- 873-32-5
- Molecular formula:
- C7H4ClN
- IUPAC Name:
- 2-chlorobenzonitrile
- Reference substance name:
- unknown
- IUPAC Name:
- unknown
- Test material form:
- solid
Constituent 1
impurity 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- not specified
- Positive controls:
- not specified
- Negative controls:
- not specified
Results and discussion
- Transformation products:
- not specified
Dissipation DT50 of parent compound
- Key result
- pH:
- 7.3
- Temp.:
- 22 °C
- DT50:
- 160 d
- Type:
- not specified
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The hydrolysis half-life for 2-chlorobenzonitrile was determined to be 160 +/- 40 d, but biologiocal degradation cannot be excluded.
- Executive summary:
Hydrolysis of 2-chlorobenzonitrile was followed by incubation of 0.14 mg/L = 1 µmol/L test substance in sediment samples of an eutrophic pond situated in the Netherlands at 22 °C and pH = 7.3. Hydrolysis was terminated by addition of acetonitrile.
The hydrolysis half-life was determined to be 160 +/- 40 d.
In control experiments in pure water with various nitriles the test substances were not hydrolyzed. Therefore, biological degradation processes cannot totally be excluded.
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