Registration Dossier
Registration Dossier
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EC number: 203-140-2 | CAS number: 103-74-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001-02-23 - 2001-10-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well-documented GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP Monitoring Authority
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Pyridine-2-ethanol
- IUPAC Name:
- Pyridine-2-ethanol
- Details on test material:
- - Physical state: liquid
- Lot/batch No.: 1280031
- Storage condition of test material: room temperature, in the dark until 31 July 2001, thereafter at approximately 4°C in the dark
- Other: Data relating to the identity, purity and stability of the test material are the responsibility of the Sponsor.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No signs of systemic toxicity have been observed during 4 h of exposure and 14 days after initiation of exposure:
Mortality Data - There were no deaths.Clinical Observations - There were no signs of systemic toxicity.
Dermal Reactions - Crust formation was noted at the treatment sites of all females two and three days after dosing. No other signs of dermal irritation were noted during the study.
Bodyweight - All animals showed expected gains in bodyweight over the study period.
Necropsy - No abnormalities were noted at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- The acute dermal median lethal dose(LD50) of the test material in the Sprague-Dawley CD (Crl: CD® (SD) IGS BR) strain rat was found to be greater than 2000 mg/kg bodyweight.
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