Registration Dossier
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EC number: 272-805-7 | CAS number: 68912-13-0
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In the decision letter from ECHA of 21 October 2021 (CCH-D-2114569822-39-01/F) an Effects on soil micro-organisms test (EU C.21./OECD TG 216) with Cyclaprop was requested. The deadline for submission is January 26th 2023, but unfortunately, the test report will not be available before that date. Quotations from several labs were requested, but due to non-availability of some labs, it took some time to find the right lab to perform the study on the shortest notice. The OECD 216 study was initiated on 16 November 2022 and the final results are expected to be available by the end of February 2023. The dossier will be updated as soon as possible after receiving the final reports. A letter from the test lab showing the timelines is attached to this endpoint summary.
Cyclaprop's long term toxicity to soil micro-organism is 100 mg/kg soil dw, based on read-across from Verdox.
Key value for chemical safety assessment
- Long-term EC10 or NOEC for soil microorganisms:
- 100 mg/kg soil dw
Additional information
The read across to Cyclaprop is presented in the Terrestrial toxicity Overall Endpoint summary. The executive summary of the Verdox study is presented below.
Verdox and its long-term toxicity to soil micro-organisms.
The toxicity of the test substance for soil microflora was tested according to OECD TG 216 using nitrogen transformation in soil. The concentrations tested were 0, 10, 32, 100, 320 and 1000 mg/kg dw soil. The reference substance was sodium chloride. The soil used was abiologically active agricultural soil: Silty sand. The effect parameter was NO3-nitrogen production after 28 days exposure (soil nitrogen transformation). Nominal concentrations were used. No statistical significant effects of the test item on nitrate content in soil were observed at day 28 up to a concentration of 100 mg Verdox/kg soil dw by Williams Multiple t-test Procedure. For concentrations of 320 mg and 1000 mg test substance/kg soil dw, the deviations to control were significant (Williams Multiple t-test Procedure). At day 28 differences in nitrogen production to the control were -30.25 %, 36.26%, 35.90% for 10-100 mg/kg soil, not significantly and not concentration related. At 320 and 1000 mg/kg dw the reduction was -99.64% and -73.94% for 320 mg and 1000 mg test substance/kg soil dw significantly though no clear dose relation. An EC10 could not be derived. The NOEC was determined to be 100 mg/kg soil dw based on nominal values.
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