Registration Dossier
Registration Dossier
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EC number: 228-845-2 | CAS number: 6362-79-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although conducted prior to current protocol or GLP requirements, the study conformed to recognized protocols current at the time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- Performed prior to current protocol or GLP requirements but by a method acceptable at the time.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium hydrogen-5-sulphoisophthalate
- EC Number:
- 228-845-2
- EC Name:
- Sodium hydrogen-5-sulphoisophthalate
- Cas Number:
- 6362-79-4
- Molecular formula:
- C8H6O7S.Na
- IUPAC Name:
- Sodium 3,5-dicarboxybenzenesulfonate
- Reference substance name:
- 288-845-2
- IUPAC Name:
- 288-845-2
- Reference substance name:
- Sodium-3,5-dicarboxybenzenesulfonate
- IUPAC Name:
- Sodium-3,5-dicarboxybenzenesulfonate
- Reference substance name:
- 5-(Sodiosulfo)isophthalic acid
- IUPAC Name:
- 5-(Sodiosulfo)isophthalic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material: 5-(Sodiosulfo)isophthalic Acid
- Appearance/Physical form: powder
- Formula Weight: 268 g/mol
- Molecular Formula: C8H6O7S-1Na
- Purity: >92% (assay)
- Impurities: sodium sulfate,- Lot/batch No.: ARK BA103-81; X-17007-226
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Male and female rats were given an aqueous solution of the test substance by gavage.
- Doses:
- 3200 mg/kg bwt
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Mortality:
- One of four male and one of four female rats died.
- Clinical signs:
- other: Clinical signs included prostration, diarrhea, rough hair coat, depressed appetite, and slight to moderate weakness post dosing.
Applicant's summary and conclusion
- Conclusions:
- The LD50 value of the test substance in male and female rats was greater than 3200 mg/kg bwt.
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