Registration Dossier
Registration Dossier
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EC number: 232-164-6 | CAS number: 7789-41-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In Ames test with calcium bromide no significant increases in revertant colony numbers over control counts were obtained with any of the tester strains following exposure to the test material dissolved in water at levels from 50 to 5000 ug per plate, either in the presence or the absence of the S-9 mix. These results are supported by a read across from sodium bromide. The following in vitro tests were performed on sodium bromide: Ames test, chromosomal aberration study, and a UDS assay. All of the results were negative for genotoxicity.
Read across from NaBr to CaBr2 is possible due to the full dissociation of both compounds in water. Na+ and Ca2+ are not toxic in the concentration ranges where Br- is toxic. Therefore only the Br- is responsible for the toxicity effects.
Short description of key information:
Assessment of mutagenic potential in histidine auxotrophs of Salmonella typhimurium (Ames test)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on a weight of evidence, Calcium bromide is not mutagenic.
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