Registration Dossier
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EC number: 210-871-0 | CAS number: 624-92-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 6.7 mg/L
- EC50 for marine water algae:
- 1.3 mg/L
- EC10 or NOEC for freshwater algae:
- 0.17 mg/L
- EC10 or NOEC for marine water algae:
- 0.95 mg/L
Additional information
Acute toxicity of DMDS to several species of marine and/or freshwater algae and diatoms has been investigated.
The most sensitive species identified for freshwater species isAnabaena flos-aquaewith an ECr50 -96h of 6.7 mg/L and a NOEC = 0.17 mg/L. Based on this result DMDS could be considered as toxic to algae.
Pseudokirchneriella subcapitatais less sensitive:
EbC 50 - 72h, based on biomass, was of 14.3 mg/L. NOEC was of 5.74 mg/L and LOEC was of 9.4 mg/L.
ErC 50 - 72h, based on growth rate, was 25.6 mg/L. NOEC was of 9.4 mg/L and LOEC was of 20.6 mg/L.
Those results are consistent with those obtained in the frame of an older study.
In a weight of evidence approach, DMDS can be considered as harmful to algae.
EC50 - 72h for biomass is of 11 mg/L and is of 35 mg/L for growth rate. NOEC is of 10.43 mg/L (Thiebaud H and Lespagnol CC, 2000).
For the freshwater diatomNavicula pelliculosa, EC 50 - 96h determined, based on cell density, was of 20 mg/L. EbC 50 - 96h, based on biomass, was of 18 mg/L, and ErC 50 - 96h, based on growth rate, was of 25 mg/L. NOAEC - 96h was of 15 mg/L (Minderhout Tet al., 2008).
Concerning marine species, after a 96 hours exposure of the marine diatomSkeletonema costatumto dimethyl disulfide, biomass was the most sensitive endpoint, as defined by the lowest EC50 value. The 96-hour EbC50, based on biomass, was 1.2 mg a.i./L, while the 96-hour EC50 and ErC50 values were 1.3 and 3.9 mg a.i./L, respectively. Since the 96-hour NOAEC values, based on cell density and biomass, were below the lowest test concentration, EC5 and EC10 were calculated and reported as conservative substitutes for the NOAEC values for these parameters. The 96-hour NOAEC, based on cell density, was 0.093 and 0.19 mg a.i./L, based on EC5 and EC10, respectively. The 96-hour NOAEC, based on biomass, was 0.074 and 0.15 mg a.i./L, based on EC5 and EC10, respectively. The 96-hour NOAEC, based on growth rate was 0.95 mg a.i./L. Therefore DMDS is considered as harmful to marine diatoms (Minderhout Tet al., 2008).
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