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Registration Dossier
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EC number: 213-424-8 | CAS number: 947-04-6
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation, other
- Remarks:
- other: 5 day repeated inhalation test
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1964
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No analytical monitoring; significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- see Test Conditions
- GLP compliance:
- no
Test material
- Reference substance name:
- Dodecane-12-lactam
- EC Number:
- 213-424-8
- EC Name:
- Dodecane-12-lactam
- Cas Number:
- 947-04-6
- Molecular formula:
- C12H23NO
- IUPAC Name:
- 1-azacyclotridecan-2-one
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- other: 20 mice, 10 rats, 2 guinea pigs, 1 rabbit, 1 cat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Animals were exposed in a 400 l room to the vapours of the test substance that were generated by heating 20 g of test substance at 160 °C.
The average loss of test substance during the daily exposure was 11.4 g. - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- 4 hours/day
- No. of animals per sex per dose:
- 20 mice, 10 rats, 2 guinea pigs, 1 rabbit, 1 cat (sex not reported)
- Control animals:
- no
- Details on study design:
- Post-exposure period: 14 days
- Positive control:
- none
Examinations
- Observations and examinations performed and frequency:
- no details reported
- Sacrifice and pathology:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- Except for minor signs of irritancy of the mucosa of nose, throat, and eyes, no signs of intoxication were observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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