Registration Dossier
Registration Dossier
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EC number: 915-035-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data was available on sensitisation testing with the reaction mass of heptachromium tricarbide and trichromium dicarbide. An OECD 406 guideline test with basic chromium(III) sulphate did not cause any skin sensitisation. Read-across to this more soluble Cr(III) compound can be done, in order to show the results of a "worst case" test. As this soluble trivalent chromium compound is not sensitising, it is highly unlikely that the poorly soluble reaction mass of heptachromium tricarbide and trichromium dicarbide would cause skin sensitisation.
The sensitisation potential of metals depends on the amount released and the reaction between the released metals and sweat.
In vitro tests have shown very low release rates of chromium from the reaction mass of heptachromium tricarbide and trichromium dicarbide
, chromium metal, and also from ferrochromium, ferrosilicochromium and stainless steel.No released Cr(VI) has been detected in any release tests.
Migrated from Short description of key information:
No cases of skin sensitisation caused by the reaction mass of heptachromium tricarbide and trichromium dicarbide have been reported. A GLP sensitisation test with trivalent basic chromium sulphate did not show any signs of skin sensitisation. A recent evaluation by WHO concluded that water-insoluble chromium(III) oxide does not cause skin sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Migrated from Short description of key information:
There are no cases of respiratory sensitisation caused by the reaction mass of heptachromium tricarbide and trichromium dicarbide or by chromium metal or trivalent chromium compounds.
Justification for classification or non-classification
No classification is suggested.
There are no indications that the reaction mass of heptachromium tricarbide and trichromium dicarbide or Cr(III) would cause sensitisation. No Cr(VI) has been detected in chromium metal release tests.
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