Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 274-641-1 | CAS number: 70516-41-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Toxicokinetic Assessment for S-205
- Reliability:
- 1 (reliable without restriction)
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no data
Results from in vivo toxicology studies performed with S-205 and an analogue substance Black 400 reveal that S-205 is poorly absorbed via the gastrointestinal tract and the skin. There is evidence of systemic distribution including to the kidneys when S-205 is administered via the oral route. The kidneys may be the site of excretion. Although S-205 log Pow indicates potential for bioaccumulation, nothing was observed in the macroscopic or microscopic investigations probably due to poor absorption across biological membranes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
