Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-572-7 | CAS number: 142-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
In a ready biodegradability test the substance was found to be 66% degraded after 28 days, and the 14-day window which applies to closed bottle tests was met. An inherent biodegradability test was conducted and the substance was found to be 85% degraded after 28 days. Thus, the substance is considered to be 'readily biodegradable'.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Ready biodegradability
A 28-day ready biodegradability study was conducted according to OECD guidelines in order to determine the biodegradability of the n-hexyl acetate. The test substance was suspended in a mineral medium at a concentration of 2.9 mg/l with an activated sludge inoculum. Blank inoculum, reference substance and toxicity control treatments were also used during this test. Test vessels were incubated in the dark at 20 ± 1oC and the dissolved oxygen content was measured on days 7, 14, 21 and 28. The biodegradation of the substance was determined based on the depletion of dissolved oxygen during this time.
The results for the reference substance and toxicity controls proved the test was valid. After 28 days the test substance was found to be 66% degraded. Graphical interpolation indicated that the 14 -day window applicable to this test had been met. As such, the substance is considered to be readily biodegradable.
Inherent biodegradability
The inherent biodegradability of hexyl acetate was determined by a manometric respirometry test according to OECD guideline 302 C. Dilutions of 30 mg/l hexyl acetate were created using inoculated medium. These were stirred and incubated at 25oC for 28 days and the rate of oxygen consumption measured using a Bioscience BI-1000 respirometer. The amount of oxygen taken up by the microbial population during biodegradation of the test substance was expressed as a percentage of the theoretical oxygen demand (ThOD) in order to determine the percentage of the test substance degraded.
The reference substance was 95% degraded within 14 days, confirming the activity of the inoculum. The test substance was found to be 85% degraded after 28 days. As such the substance can be classified as inherently biodegradable.
QSAR estimation of biodegradability
A QSAR estimation of the biodegradability of hexyl acetate was conducted using Biowin v4.10. The following SMILES and chemical structure was used: O=C(OCCCCCC)C
All of the models within Biowin v4.10 predict that hexyl acetate will biodegrade quickly. Hence, Biowin v4.10 predicts that the substance is readily biodegradable. This indicates that the structure of hexyl acetate is susceptible to rapid breakdown by environmental microorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)