Registration Dossier
Registration Dossier
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EC number: 252-038-4 | CAS number: 34452-51-2
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- see attached justification
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Materials and methods
Test material
- Reference substance name:
- Potassium mercaptoacetate
- EC Number:
- 252-038-4
- EC Name:
- Potassium mercaptoacetate
- Cas Number:
- 34452-51-2
- Molecular formula:
- C2H4O2S.K
- IUPAC Name:
- potassium sulfanylacetate
Constituent 1
Results and discussion
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 23 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical biochemistry
- haematology
- histopathology: non-neoplastic
- mortality
- Remarks on result:
- other: corrected for molecular weight differences
- Dose descriptor:
- LOAEL
- Effect level:
- 68 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical biochemistry
- haematology
- histopathology: non-neoplastic
- mortality
- Remarks on result:
- other: corrected for molecular weight differences
Target system / organ toxicity
- Key result
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 68 mg/kg bw/day (actual dose received)
- System:
- hepatobiliary
- Organ:
- liver
- Treatment related:
- yes
- Dose response relationship:
- yes
- Relevant for humans:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Based on data for NaTG, the subchronic oral NOAEL of KTG is assumed to be 23 mg/kg bw/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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