Registration Dossier
Registration Dossier
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EC number: 261-245-9 | CAS number: 58430-94-7
Endpoint summary
Administrative data
Description of key information
The registration item was not acutely toxic to animals.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 250 mg/kg bw
- Quality of whole database:
- The available study is considered as reliable with some restrictions.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The available study is considered as reliable with some restrictions.
Additional information
The substance 3,5,5,-trimethylhexyl acetate was not acutely toxic to rats in a reliable and valid acute oral toxicity study and the oral LD50 value was 4250 mg/kg bodyweight. In addition, the substance was not acutely toxic in a reliable and valid acute dermal toxicity study in rabbits with a dermal LD50 value >5000 mg/kg body weight. Information about the acute inhalation toxicity of the substance is not available. However, dermal and oral routes of exposure are considered to be the most likely routes of human exposure to this fragrance substance. Overall, the registration item exhibits low acute toxicity.
Justification for classification or non-classification
Classification,
Labelling, and Packaging Regulation (EC) No 1272/2008
The
available experimental test data are reliable and suitable for
classification purposes under Regulation (EC) No 1272/2008. Based on
available data on acute toxicity, the test item is not classified according
to Regulation (EC) No 1272/2008 (CLP), as amended for the eighth time in
Regulation (EU) No 2016/918.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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