Registration Dossier
Registration Dossier
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EC number: 292-637-8 | CAS number: 90641-13-7 A complex combination of hydrocarbons produced by the distillation of the products from a steam cracking process thereafter treated with hydrogen in the presence of a catalyst. It consists predominantly of aromatic hydrocarbons having carbon numbers in the range of C9 through C10 and boiling in the range of approximately 140°C to 200°C (284°F to 392°F).
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP near guideline study available as unpublished report (in German) but otherwise fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal: 7, 31.6, 52.2, 78.3, 104.4 mg/L
Analysed: 6.08, 20.00, 23.98, 38.87, 61.80 mg/L - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Statistics:
- Probit analysis based on Finney (1971)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 28.1 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: 5/20 mortalities at 23.98 and 18/20 mortalities at 38.87 mg/L
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 25.7 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: 3/10 mortalities at 23.98 and 10/10 at 38.87 mg/L
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 30 mg/L air (analytical)
- 95% CL:
- 25.5 - 36.8
- Exp. duration:
- 4 h
- Remarks on result:
- other: 2/10 mortalities at 23.98 and 8/10 mortalities at 38.87 mg/L
- Mortality:
- Mortality at 6.08, 20.00, 23.98, 38.87, 61.80 mg/L
Males: 0/10, 1/10, 3/10, 10/10, 10/10
Females: 0/10, 1/10, 2/10, 8/10, 10/10 - Clinical signs:
- other:
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute inhalation LC50 > 20 mg/L
- Executive summary:
Acute inhalation toxicity of toluene was investigated in 5 groups of 10 male and female rats exposed for 4 hours at concentrations of 6.08, 20.00, 23.98, 38.87 or 61.80 mg/L.
Adverse clinical signs and mortality were seen at concentrations of 20 mg/L and above. All surviving animals were normal by day 3. The LC50 exceeded 20 mg/L (25.7 mg/L in males, 30 mg/L in females).
Toluene does not warrant classification under GHS/CLP.
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