Registration Dossier
Registration Dossier
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EC number: 231-102-5 | CAS number: 7439-93-2
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- lithium chloride and sodium hypochlorite generating lithium hypochlorite
- IUPAC Name:
- lithium chloride and sodium hypochlorite generating lithium hypochlorite
- Reference substance name:
- Lithium hypochlorite
- EC Number:
- 237-558-1
- EC Name:
- Lithium hypochlorite
- Cas Number:
- 13840-33-0
- Molecular formula:
- ClHO.Li
- IUPAC Name:
- lithium hypochlorite
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- other: humans
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- other: exposed in a spa ("bathing water" at 101+/-2°F equivalent to ca. 38.4°C)
- Vehicle:
- water
- Duration of exposure:
- 20 minutes/day, 4 days/week for two consecutive weeks
- Doses:
- ca. 40 mg lithium / L
- Control animals:
- yes
- Details on study design:
- Control spa: 0.02 ppm lithium
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- no effects
Any other information on results incl. tables
There was no statistically significant difference in serum lithium levels between the control and treatment group at any stage. The pre-treatment levels of about 1 to max. 8 µg lithium / L serum were not exceeded after treatment.
Applicant's summary and conclusion
- Conclusions:
- Lithium ion is very unlikely to penetrate skin.
- Executive summary:
No significant elevation of serum lithium levels was reported in 53 healthy volunteers spending 20 minutes/day, 4 days/week for two consecutive weeks in a spa with a concentration of approximately 40 mg lithium / L as compared with unexposed controls. The study result confirms the very low skin absorption for inorganic lithium salts, as discussed in the key study.
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