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EC number: 203-268-9 | CAS number: 105-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Justification for type of information:
- The Human Repeat Insult Patch Test (HRIPT) is a well-accepted sensitization method using human voulenteers as test subjects
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Human Repeat Insult Patch Test
- Principles of method if other than guideline:
- Human voulenteers have a test article applied to their skin to judge the potential for skin sensitization reactions.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cyclohex-1,4-ylenedimethanol
- EC Number:
- 203-268-9
- EC Name:
- Cyclohex-1,4-ylenedimethanol
- Cas Number:
- 105-08-8
- Molecular formula:
- C8H16O2
- IUPAC Name:
- cyclohexane-1,4-diyldimethanol
- Reference substance name:
- [4-(hydroxymethyl)cyclohexyl]methanol
- IUPAC Name:
- [4-(hydroxymethyl)cyclohexyl]methanol
- Reference substance name:
- Cyclohexane-1,4-dimethanol; 1,4-Bis(hydroxymethyl)cyclohexane; CHDM
- IUPAC Name:
- Cyclohexane-1,4-dimethanol; 1,4-Bis(hydroxymethyl)cyclohexane; CHDM
- Details on test material:
- -Radioactive test substance as purchased: [Methylol-[14]C] 1, 4-cyclohexanedimethanol
-Source: New England Nuclear, Boston, MA
-Composition as purchased: isomeric mixture of 70% cis- and 30% trans-CHDM
-Specific activity: 7.55 µC/mg
-Purity: >98%
-Radioactive test substance used for dosing: [14]C CHDM isomers were separated by gas chromatography using a thermal conductivity detector and a trapping device; each separated isomer had a purity of >95% when measured by gas chromatography with flame ionization detector. The isomers were combined in a 70% trans-and 30% cis-isomer mixture (to conform with the non-labeled CHDM-R sold by Eastman Organic Chemicals).
-Non-radioactive CHDM used for dosing: mixture of 70% trans- and 30% cis-isomers
-Source: Eastman Organic Chemicals, Rochester, NY
Constituent 1
Constituent 2
Constituent 3
- Specific details on test material used for the study:
- 1,4-Cyclohexanedimethanol CAS Registry No. 105-08-8 Batch# TP07052372
Method
- Type of population:
- general
- Ethical approval:
- confirmed and informed consent free of coercion received
- Subjects:
- Participants: Two hundred eleven (211) subjects completed this study. The remaining subjects discontinued their participation for various reasons, none of which were related to the application of the test material.
- Clinical history:
- Inclusion Criteria:
a. Male and female subjects, age 16• and over.
b. Absence of any visible skin disease which might be confused with a skin reaction from the test material.
c. Prohibition of use of topical or systemic steroids and/or antihistamines for at least seven days prior to study initiation.
d. Completion of a Medical History form and the understanding and signing of an Informed Consent form.
e. Considered reliable and capable of following directions.
Exclusion Criteria:
a. Ill health.
b. Under a doctor's care or taking medication(s) which could influence the outcome of the study.
c. Females who are pregnant or nursing.
d. A history of adverse reactions to cosmetics or other personal care products. - Route of administration:
- dermal
Results and discussion
- Results of examinations:
- Under the conditions of this study, test material, I, 4-Cyclohexanedimethanol
CAS Registry No. I 05-08-8 Batch# TP07052372, did not indicate a potential for
dermal irritation or allergic contact sensitization.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, test material, I, 4-Cyclohexanedimethanol
CAS Registry No. I 05-08-8 Batch# TP07052372, did not indicate a potential for
dermal irritation or allergic contact sensitization. - Executive summary:
Under the conditions of this study, test material, I, 4-Cyclohexanedimethanol CAS Registry No. I 05-08-8 Batch# TP07052372, did not indicate a potential for dermal irritation or allergic contact sensitization.
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