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Long-term toxicity to aquatic invertebrates

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Description of key information

One long term toxicity test with daphnia has been performed. The 21 d NOEC  for reproduction is 320 µg/L based on the test substance (100% purity). For parental mortality an EC10 was observed of 279 µg/L. This value will be used as a worst-case for the hazard assessment. The effects are expressed as nominal values because the tests were performed with river water as they are intended to be used in an evaluation of the environmental risks based on the Bulk approach.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
279 µg/L

Additional information

The daphnia reproduction test result shows that at 1000 mg/L, 100% of the parental daphnids were immobile within 5 days, while at the next lower test concentration of 320 µg/L there are only two immobile daphnia observed after 19 days and there is no detrimental effect on reproduction when compared to the control. These observations lead to the derivation of a NOEC of 320 µg/L and an EC50 (21 d) of 405 µg/L resulting in a low acute-to-chronic ratio. A low acute-to-chronic ratio is indicative of a non-specific mode of action and is often associated with non systemic effects. This observation is consistent with the known effects of cationic surfactants on aquatic organisms, where toxicity is associated with physical binding to respiratory membranes. This explains the steep concentration curves seen and the lack of intermediate chronic effects on reproduction.