Registration Dossier
Registration Dossier
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EC number: 231-667-8 | CAS number: 7681-49-4
Endpoint summary
Administrative data
Description of key information
Fluoride salts are not considered irritants to the skin or eyes based on results of rabbit skin and eye irritation testing.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In rabbits (Allied Corp., 1983), no signs of skin corrosion or skin irritation (erythema and/or edema) were observed after a 4 -hour topical (occluded) exposure to potassium bifluoride. The skin was observed and scored for signs of irritation/corrosion immediately after patch removal and again at 48 hours after patch removal.
In a rabbit eye irritation test (Proctor & Gamble, 1971), in which an undiluted liquid test material containing 1% phosphate (as sodium phosphate) and 100 ppm fluoride (as sodium fluoride) was applied to the eyes, very mild irritaiton (slight conjunctivitis) was produced in two of three test eyes 1 hour after dosing. No signs of irritation were visible 24 hours later; the eye irritation was fully reversible.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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