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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyrithione zinc
EC Number:
236-671-3
EC Name:
Pyrithione zinc
Cas Number:
13463-41-7
Molecular formula:
C10H8N2O2S2Zn
IUPAC Name:
Bis [1-hydroxy-2(1H)-pyridinethionato-O,S](T-4)-zinc
Details on test material:
Purity: 48% zinc pyrithione in aqueous suspension

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Source: Ace Animals
Weight at study initiation: Males - 200-300g Females - 212-286g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Post-exposure period: 14 days
Doses:
Concentrations: 125, 158, 200, 254, and 321 mg/Kg
Dose volume: 0.04 - 0.15ml depending on dose and animal weight
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
302 mg/kg bw
95% CL:
210 - < 435
Sex:
female
Dose descriptor:
LD50
Effect level:
221 mg/kg bw
95% CL:
169 - < 288
Sex:
male/female
Dose descriptor:
LD50
Effect level:
269 mg/kg bw
95% CL:
205 - < 352
Mortality:
All of the deaths occurred by day 5 for the animals that died during the observation period. The deaths were preceded by signs of ptosis, diarrhea, lethargy, piloerection, chromomdacryorrhea, chromorhinorrhea, emaciation, soiling of the body surfaces, and wetness and brown staining of the anogenital area. Necropsy of the deaths revealed abnormalities of the lungs, liver, spleen and gastrointestinal tract, as well as red and brown staining of the nose/mouth area and staining of the anogenital area
Clinical signs:
other: Physical signs in the surviving animals included ptosis, diarrhea, lethargy, piloerection, chromomdacryorrhea, chromorhinorrhea, emaciation, ataxia, bloated abdomen, alopecia, ocular abnormalities, alopecia of ventral surfaces, soiling of the body surface
Gross pathology:
Necropsy results of the surviving animals dosed with 125 mg/Kg were normal. Results from the other groups showed abnormalities of the spleen, adhesions in the peritoneal cavity, alopecia of ventral surfaces, brown staining of the anogenital area, and red staining around the eyes.

Applicant's summary and conclusion

Conclusions:
LD50 = 269 mg/kg bw. The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under Regulation EC 1907/2006.