Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
1.88 mg/L
Assessment factor:
50
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
6.33 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.188 mg/L
Assessment factor:
500
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
100 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
6.956 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.696 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.304 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

According to Article 13 of Regulation (EC) No. 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of substances", Information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met. Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. This avoids the need to test every substance for every endpoint”. Since the analogue concept is applied to the target substance Reaction mixture of Glycerol 1,3-di(acetate), glycerol acetate and triacetin, data will be generated from a representative read-across substances to avoid unnecessary animal testing. Additionally, once the analogue concept is applied, substances will be classified and labelled on this basis.

Degradation

Biodegradation: Readily biodegradable, 81 - 108.5% of Reaction mixture of Glycerol 1,3-di(acetate), glycerol acetate and triacetin(OECD 306)

Bioaccumulation

Log Kow: -1.24 - 0.36 (KOWWIN v1.68)

Aquatic acute toxicity

96 h, LC50 (Scophthalmus maximus): > 1000 mg/L (nominal)

72 h, EC50 (Skeletonema costatum): 632.5 mg/L (nominal)

48 h, EC50 (Acartia tonsa): > 2000 mg/L (nominal)

Aquatic chronic toxicity

21 d, NOEC (Daphnia magna): ≥ 94 mg/L (measured; read-across)

72 h, NOEC (Skeletonema costatum): 100 mg/L (nominal)

 

Classification justification according to CLP and DSD

Based on the data above, Reaction mixture of Glycerol 1,3-di(acetate), glycerol acetate and triacetin is considered to be rapidly degradable. The acute aquatic toxicity L(E)C50 values are > 1 mg/L for fish, algae and aquatic invertebrates. Valid chronic data are available for aquatic algae and invertebrates with NOECs > 1 mg/L. Therefore, Reaction mixture of Glycerol 1,3-di(acetate), glycerol acetate and triacetin does not need to be classified and labelled as environmental hazard according to the 2nd ATP of Regulation (EC) No. 1272/2008 (CLP) and Directive 67/548/EEC.