Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-605-4 | CAS number: 85-43-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD 401 with acceptable restrictions mostly due to reduced reporting in times before GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2,3,6-tetrahydrophthalic anhydride
- EC Number:
- 201-605-4
- EC Name:
- 1,2,3,6-tetrahydrophthalic anhydride
- Cas Number:
- 85-43-8
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1,3,3a,4,7,7a-hexahydro-2-benzofuran-1,3-dione
- Details on test material:
- - Name of test material (as cited in study report):Tetrahydrophthalsäure-anhydrid (Tetra hydro phthalic acid anhydride)
- Physical state: solid
- Analytical purity: 98 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 233 +/-34.7 g (male); 203 +/- 38.7 (female)
- Fasting period before study: not reported, probably overnight before dosing
- Housing: groups
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
Not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous suspension of 1% Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2% ,16% and 20 % w/Vol.
- Justification for choice of vehicle: not given probably solubility
MAXIMUM DOSE VOLUME APPLIED: 6.9 mL - Doses:
- 200, 1600, 3200, 6400 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days (not supposed to have an influence on the result)
- Frequency of observations and weighing: only at study initiation for dose calculation
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 mg/kg : 0/10
1600 mg/kg: 0/9
3200 mg/kg 5/10
6400 mg/kg 10/10 - Clinical signs:
- other: at toxic doses: Dyspnoea; abdominal position, staggering
- Gross pathology:
- animal sacrificed at study termination: nothing abnormal detected
animals that died: gastro intestinal irritation; corrosive effects
Applicant's summary and conclusion
- Conclusions:
- The LD50 following administration of a single oral dose to rats was approximately 3200 mg/kg body weight
- Executive summary:
Acute oral toxicity has been investigated using methods similar to those described in OECD/EU test guidelines. The LD50 following administration of a single oral dose to rats was approximately 3200 mg/kg body weight
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
