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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1379
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: 2d Meets national standard methods with acceptable restrictions. Purity of test substance is not given.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Method: other: see test conditions
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Valeric acid
EC Number:
203-677-2
EC Name:
Valeric acid
Cas Number:
109-52-4
Molecular formula:
C5H10O2
IUPAC Name:
pentanoic acid
Details on test material:
n-valeric acid, no data on purity

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Weight at study initiation: males: 227 g; female 186 g

Administration / exposure

Details on dermal exposure:
Test substance was applied on the clipped skin of the back under occlusive conditions over 24 hrs.
Duration of exposure:
Test substance was applied on the clipped skin of the back under occlusive conditions over 24 hrs.
Doses:
2000, 4000 mg/kg bw
No. of animals per sex per dose:
6
Details on study design:
Test substance was applied on the clipped skin of the back under occlusive conditions over 24 hrs.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
4000 mg/kg: all 3 male animals died within 24 hours, all 3 female animals died within 48 hours. 
2000 mg/kg: males and females: no death
Clinical signs:
other: Clinical signs: irregular breathing, giddiness, atonia, narcotic-like behaviour, insensibility to pain, rough coat, diarrhea, exsiccation, hemafecia. 
Gross pathology:
The dermal application caused necrosis.  Macroscopic examination after 14 d: heart dilatation and venous congestions in moribund animals.

Any other information on results incl. tables

RS-Freetext:
LD50 >2000 mg/kg bw and < 4000 mg/kg bw
Mortality: 4000 mg/kg: all 3 male animals died within 24
hours, all 3 female animals died within 48 hours. 2000 mg/kg
males and females: no death
Clinical signs: irregular breathing, giddiness, atonia,
narcotic-like behaviour, insensibility to pain, rough coat,
diarrhea, exsiccation, hemafecia. 
The dermal application caused necrosis. 
Macroscopic examination after 14 d: heart dilatation and
venous congestions in moribund animals.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 of n-valeric acid is >2000 mg/kg.