Registration Dossier
Registration Dossier
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EC number: 244-787-0 | CAS number: 22113-87-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Monomethylamine and nitrate, as separate compounds, do not induce any mutagenic effects on in vitro systems by themselves. Besides, it has been demonstrated that ammonium nitrate, which is very close to methylammonium nitrate in its structure and behaviour, is not at all mutagenic to standard in vitro systems.
The overall information leads to the conclusion that methylammonium nitrate is undoubtedly non mutagenic to in vitro systems, and that further testing is not necessary.
Short description of key information:
Results obtained in vitro:
- Methylamine: negative in bacteria
- Nitrate: negative in bacteria and mammalian cells
- Ammonium nitrate: negative in bacteria
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The overall results show that methylamine nitrate is unlikely to cause mutations in in vitro systems. It can be assumed that methylamine does not have to be classified for germ cell mutagenicity, due to the negative results obtained with methylamine, nitrate and ammonium nitrate.
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