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EC number: 939-273-4 | CAS number: -
The acute toxicity of PARAFFIN WAXES AND HYDROCARBON WAXES, CHLORO, SULFOCHLORINATED SAPONIFIED (C14-C17) SSP-SAMPLE 1 was investigated following a single oral administration (10 mL/kg in corn oil) to the Sprague Dawley rat followed by a 14-day observation period.
A sighting study was performed in which a single female animal was dosed at 2000 mg/kg. No mortality and no clinical signs were seen during the observation period.
A main study was then performed on an additional 4 females which were dosed at 2000 mg/kg. No mortality occurred. No clinical signs considered related to the toxicity of the test item were noted during the observation period.
The body weight changes observed in the animals were not remarkable with the exception of body weight loss observed in a single animal showing signs that could be unrelated to the toxicity of the test item. All animals were killed at the end of the observation period and subjected to necropsy examination. No abnormalities were observed at the necropsy examination performed on termination of the observation period in 4 out of 5 animals treated. In the remaining animal, swollen abdomen, gas content and swelling were observed in the gastrointestinal tract.
These results indicate that the test item, PARAFFIN WAXES AND HYDROCARBON WAXES, CHLORO, SULFOCHLORINATED SAPONIFIED (C14-C17) SSP-SAMPLE 1, has no toxic effect on the rat following oral administration of single doses of 2000 mg/kg. The lack of mortality demonstrates the LD50 to be greater than 2000 mg/kg body weight.
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