Registration Dossier
Registration Dossier
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EC number: 250-418-4 | CAS number: 30989-05-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1974
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Increase in substance weight instead of decrease during IRT, probably due to hygroscopic properties of test substance. Therefore, one cannot be sure whether the animals were exposed to the test substance at all.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- GLP compliance:
- no
- Test type:
- other: Inhalation Risk Test (IRT)
- Limit test:
- no
Test material
- Reference substance name:
- Tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate
- EC Number:
- 250-418-4
- EC Name:
- Tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate
- Cas Number:
- 30989-05-0
- Molecular formula:
- C21H45BO12
- IUPAC Name:
- tris{2-[2-(2-methoxyethoxy)ethoxy]ethyl} borate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Substance type: Borated Glycol Ether
- Physical state: Clear colourless liquid
- Lot/batch No.: 4200 (SNC Sample No.); Indent 9450/9486
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Gassner-Ratten (Gassner-rat)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 200 liter air/hour
"Inhalation einer mit Dampf bei C gesättigten Atmosphäre: 20 °C. Zur Sättigung wurde durch eine ca. 5 cm hohe Schicht des Produktes Luft geleitet"
(Inhalation of a vapour saturated atmosphere at 20 °C. In order to obtain saturation of the atmosphere, air was passed through a 5 cm column of the product.) - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
- Remarks:
- Exposure to pure air.
- Details on study design:
- - Exposure time: 8 h
- Duration of observation period following administration: 7 days
Further details were not provided.
Results and discussion
- Mortality:
- No mortality within 8 h exposure period and 7 day observation period.
- Clinical signs:
- other: No effects on clinical signs.
- Body weight:
- No effects on body weight.
- Gross pathology:
- No effects on gross pathology.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- No mortalities within 8 h exposure period.
- Executive summary:
A nominal concentration could not be calculated because the substance gained weight instead of lost weight during the test.
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