Registration Dossier
Registration Dossier
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EC number: 201-180-5 | CAS number: 79-14-1
Toxic effects on livestock and pets
Administrative data
Description of key information
Glycolic acid has been tested in subacute studies on rats, cats, mice and dogs. The reviews of glycolic acid toxicology indicate rats are the most sensitive species and studies confirm that kidneys are the target organ for glycolic activity with oxaloacetate deposition as the primary renal change.
Additional information
Glycolic acid has been tested in subacute studies on rats, cats, mice and dogs. The reviews of glycolic acid toxicology indicate rats are the most sensitive species and studies confirm that kidneys are the target organ for glycolic activity with oxaloacetate deposition as the primary renal change.
The effects of ethylene glycol poisoning are a concern in small animal veterinary practices with cats being more sensitive than dogs for common household pets. Glycolic acid is an intermediate step in the formation of calcium oxalate monohydrate crystalluria. The use of glycolic acid may require good husbandry steps to be followed to ensure small animals/pets are not exposed to excess amounts of glycolic acid by oral ingestion (e.g. licking cleaned surfaces). However, the diagnosis of such events, the requisite treatment and normal prognoses are well-known and no additional studies are considered appropriate to determine effects in pets and livestock consequent to exposure to glycolic acid. Since many animal feedstuffs will contain food items that themselves contain glycolic acid, it should be remembered that background exposure to glycolic acid through normal diet is relatively high (human dietary exposure = 1 mg/kg bw/day, animals are likely to have similar levels).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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