Registration Dossier
Registration Dossier
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EC number: 204-002-4 | CAS number: 112-75-4
Mode of degradation in actual use
Administrative data
- Endpoint:
- mode of degradation in actual use
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- From 01 NOV 1993 to 20 DEC 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented research report on microbial degradation of the registration substance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: Research according to standard methods
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Enzyme assay
- GLP compliance:
- no
- Remarks:
- research study well documented
- Type of study / information:
- Research on Metabolism of Dodecyldimethylamine using standard methods
Test material
- Reference substance name:
- Dodecyldimethylamine
- EC Number:
- 203-943-8
- EC Name:
- Dodecyldimethylamine
- Cas Number:
- 112-18-5
- Molecular formula:
- C14H31N
- IUPAC Name:
- N,N-dimethyldodecan-1-amine
Constituent 1
Results and discussion
Any other information on results incl. tables
Identification of Strain MA3
An isolate was obtained in pure culture by streaking the enrichment culture on agar plates containing mineral salts and dodecyldimethylamine.
Oxidative cleavage of C alkyl-N bond
Cells grown on dodecyldimethylamine readily oxidized dodecyldimethylamine to dimethylamine, dodecanal and dodecanoic acid.
Applicant's summary and conclusion
- Executive summary:
Pseudomonas MA3 is capable to use dodecyldimethyl amine as sole carbon and energy source oxidizing and cleaving the substance to dodecanal, dodecanoic acid and dimethylamine. Dodecanoic acid as a fatty acid is subsequently biodegraded by beta oxidation. The C alkyl - N bond is cleaved with help of a dehydrogenase. The metabolites dodecanal and dodecanoic acid were identified using specific enzyme inhibitors to stop further metabolism. Dimethylamine was determined by GC.
Finally the intermediate metabolites will be mineralised which means that Dodecyldimethylamine is ultimately biodegraded.
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