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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: OSHA Toxicity Screening Test. Limited documentation of the study. No detailed description of the test substance available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Guideline:
other: OSHA Toxicity Screening Test
GLP compliance:
no
Remarks:
pre-GLP
Test type:
other: single dose
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Dodecyl pentadecyl methacrylate
IUPAC Name:
Dodecyl pentadecyl methacrylate
Test material form:
other: liquid

Test animals

Species:
rabbit
Strain:
other: albino rabbits
Sex:
male

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Remarks:
undiluted
Doses:
Dosage: 5000 mg/kg
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0, 7 and 14 days
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
In the observation period of 14 days, 1 of 6 experimental animals died.
Clinical signs:
other: Dodecyl pentadecyl methacrylate was severely irritating to the skin of the albino rabbit. Skin changes at 24 hours were characterized by pale red to red, well-defined erythema, moderate edema and second degree burns. Escharosis, wrinkling and fissuring we
Gross pathology:
Necropsy examination revealed hemorrhaged lungs in rabbit No. 2 and 3; and emaciation and depletion of body fat stores in rabbit No. 3, 4 and 6.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In an acute dermal toxicity study with Dodecyl pentadecyl methacrylate with male albino rabbits, an LD50 > 5000 mg/kg was observed.
Executive summary:

In an acute dermal OSHA toxicity screening test with Dodecyl pentadecyl methacrylate (purity: unknown), the test substance was administered undiluted with a dosage of 5000 mg/kg. b.w.

The determined LD50 was > 5000 mg/kg in male albino rabbits.

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