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EC number: 289-339-5 | CAS number: 87741-01-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Data are not available to demonstrate that 1,3-butadiene is readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
As 1,3-butadiene is a gas at standard temperature and pressure conducting a standard ready biodegradability test is technically difficult, and based on exposure estimates the test may not be relevant. An OECD TG 301D closed bottle test (MITI, 2001) reported 0 - 4% biodegradation over 28 days. We have been unable to obtain a copy of the original report in order to assess its reliability.
In the absence of a standard study the use of a QSAR model to predict the biodegradability of 1,3-butadiene is an appropriate technique to use as part of a weight of evidence approach to fulfil this endpoint requirement. The use of Biowin is appropriate for 1,3-butadiene as this compound falls within the applicability domains of this model. Results from QSAR models are generally used to confirm persistence, rather than to indicate ready biodegradation. The results from the Biowin model do not indicate that 1,3-butadiene would be expected to be persistent.
In addition, various researchers have isolated microorganisms that are capable of metabolising 1,3-butadiene. One group (Houet al., 1983) demonstrated that microorganisms can biodegrade 1,3-butadiene under aerobic conditions, however, the study did not follow a standard test guideline for ready biodegradability. This results add to the weight of evidence that 1,3-butadiene has the potential to biodegrade if released to the environment.
Ready biodegradation of 1,3-butadiene has not been demonstrated and for the purposes of the risk assessment ready biodegradability will not be assumed. This was also the approach followed in the EU RAR for 1,3-butadiene (2002), which concluded that there were insufficient data to determine whether or not 1,3-butadiene would be classed as readily biodegradable. The EU RAR thus assumed that no biodegradation of 1,3-butadiene would occur (a biodegradation rate of 0).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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