Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: documentation insufficient for assessment

Data source

Reference
Title:
No information
Author:
Sternitzke AK et al.(1992). Effects of phenolic smoke condensates on hepatic drug metabolizing system. Fd. Chem. Toxicol. 30, 771-781

Materials and methods

Principles of method if other than guideline:
According to Lorke D (1983). Archives of Toxicology 54, 275-287.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male

Administration / exposure

Route of administration:
subcutaneous
Doses:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
350 mg/kg bw

Applicant's summary and conclusion