Butane-1,3-diol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Study initiation date: 29 June 2009 Study completion date: 28 October 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-Guideline Study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted on 27 July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Directive 92/69/EEC, Official Journal L 383 A 1992

Deviations:

no

Principles of method if other than guideline:

Since it was not possible to receive an aqueous mixture with undissolved test item, two 1 : 1 mixtures were prepared. The mixtures were shaken for 1 min, then equilibrated at 20 ± 0.5 °C for 69 h. No
phase separation was observed.

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

Storage: at approx. 4 °C/ cool; at room temperature

Key result

Water solubility:

>= 50 other: % (w/w)

Conc. based on:

test mat.

Loading of aqueous phase:

1 000 g/L

Temp.:

20 °C

pH:

6.1

Details on results:

The water solubility of the test item was determined according to OECD guideline no. 105 [adopted
on 27 July 1995] and EU test method A.6 [Directive 92/69/EEC, Official Journal L 383 A 1992] with
the modified flask method.
The test item is miscible in a 1 : 1 ratio mixture (w/w) with water (at 20°C).

Details on measurements:

Sample no	Amount of test item [g]	Added volume of water [ml]	Analysed carbon concentration [% C w/w]	Concentration of the test item [% w/w]^1)	pH value^2)
1	5.015	5	26.8	51.6	6.13
2	5.068	5	27.0	52.0	6.15

1) calculated from the carbon concentration of the sample solutions and the carbon content of the pure test item ~51.9 %)

2) The purified water used for the tests had a pH value of 6.46.

Conclusions:

Interpretation of results: miscible
The test item is miscible in a 1 : 1 ratio mixture (w/w) with water (at 20°C).

Executive summary:

The water solubility of the test item was determined according to OECD guideline no. 105 [adopted on 27 July 1995] and EU test method A.6 [Directive 92/69/EEC, Official Journal L 383 A 1992] with the modified flask method. The test item is miscible in a 1 : 1 ratio mixture (w/w) with water (at 20°C).

Description of key information

Water solubility (OECD 105): > 0.50 g/cm^3 at 20 °C

Key value for chemical safety assessment

Water solubility:

500 g/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item was determined according to OECD guideline no. 105 [adopted on 27 July 1995] and EU test method A.6 [Directive 92/69/EEC, Official Journal L 383 A 1992] with the modified flask method. The test item is miscible in a 1 : 1 ratio mixture (w/w) with water (at 20°C).

From the additon of equal weights of test item and water (ca. 5 g test item added to 5 mL of water) in duplicate samples, test item concentration was determined by carbon analysis (results: 51.6 and 52 % w/w). From a densitiy of the test item close to 1, a solubility related to volume of ca. >= 0.5 g/mL or >=500 g/L was estimated.