Ethyl 2-cyanoacrylate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Key result

Water solubility:

24 µg/L

Temp.:

20 °C

pH:

6.6

The average water solubility of the test item Ethyl 2 -cyanoacrylate determined on two flow rates (25 mL/h and 12.5 mL/h) is 0.024 mg/L (24 µg/L, 24 ppb).

Annotation:

Due to its high reactivity, ethyl 2 -cyanoacrylate immediately polymerizes when getting in contact with water. Thus, the reported value of water solubility represents the very small concentration of residual monomers which are detectable in the aqueous phase. It has to considered that the test item ethyl 2 -cyanoacrylate is stabilized with hydrochinone according to the test certicicate supplied by the sponsor.

Conclusions:

Interpretation of results: insoluble (< 0.1 mg/L)
The average water solubility of the test item Ethyl 2 -cyanoacrylate determined on two flow rates (25 mL/h and 12.5 mL/h) is 0.024 mg/L (24 µg/L, 24 ppb).
Annotation:
Due to its high reactivity, ethyl 2 -cyanoacrylate immediately polymerizes when getting in contact with water. Thus, the reported value of water solubility represents the very small concentration of residual monomers which are detectable in the aqueous phase. It has to considered that the test item ethyl 2 -cyanoacrylate is stabilized with hydrochinone according to the test certicicate supplied by the sponsor.

Key value for chemical safety assessment

Water solubility:

24 µg/L

at the temperature of:

20 °C